Department of Neurology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea
Varicella-zoster virus (VZV) encephalitis is uncommon in healthy adults. A previously healthy 21-year-old woman presented whole body skin rash with headache, nausea, and vomiting followed by tingling sensation in right upper and lower limbs. The cerebrospinal fluid (CSF) revealed lymphocytic pleocytosis and brain magnetic resonance imaging presented multifocal lesions in left fronto-parietal cortex. Although the diagnosis of varicella-zoster virus encephalitis was not confirmed by polymerase chain reaction analysis or antibody test of CSF, the typical skin rash of VZV, and abnormal CSF and MRI results indicated VZV induced encephalitis. Acyclovir and high-dose corticosteroid gave good improvement. This is a case of varicella-zoster virus encephalitis in a healthy patient presenting with typical rash and clinic-radiologic features of encephalitis.
Journal of Multiple Sclerosis 2(2):52-55, 2011