Progressive Cerebellar Atropy in a Patient with Neuromyelitis Optica Spectrum Disorder
Jong-Hwa Shin, MD, Jin Myoung Seok, MD, Eun Bin Cho, MD, Hye Lim Lee, MD, Hye-Jin Cho, MD,
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Neuromyelitis optica (NMO) is an inflammatory, demyelinating disease of the central nervous system
characterized by attacks of optic neuritis and myelitis and the presence of antiaquaporin-4 antibody
(anti-AQP4).There is paucity of data on patterns of brain or cerebellar atrophy in NMO, although
previous studies revealed significant brain atrophy in multiple sclerosis. We report a patient
with anti-AQP4 positive NMO spectrum disorder, who presented with generalized limb ataxia and
gait disturbance and showed progressive cerebellar atrophy in serial follow-up brain magnetic resonance
imagings.
Journal of Multiple Sclerosis 7(1):18-20, 2016
