No Evidence Disease Activity as a Treatment Target in Multiple Sclerosis
Chang Hun Bin, MD, Min Su Park, MD
Department of Neurology, Yeungnam University College of Medicine, Daegu, Korea
No evidence of disease activity (NEDA) in multiple sclerosis (MS) means no relapse, no disability
progression, and no new or enlarging lesions on MRI. NEDA is the treatment target in many inflammatory
diseases, such as rheumatoid arthritis and inflammatory bowel disease. Now, aggressive
early disease modifying therapy is acceptable for treatment of MS to prevent the irreversible
damage that leads to disability. As new and more effective therapies for MS become available,
the treatment paradigm of MS can be expected to shift, such that NEDA or freedom of disease activity
and NEDA is becoming an important measure in clinical trials. NEDA is an important goal for treating
MS and a decision method of switching disease modifying therapy. There are many unsolved
problems in NEDA and definition of NEDA would be changing by further new technologies and
studies.
Journal of Multiple Sclerosis 6(2):23-28, 2015
keyword : No evidence of disease activity, Disease free state, Multiple sclerosis
