Department of Neurology, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang, Korea
Magnetic resonance imaging (MRI) has rapidly become a leading research tool in the investigation
of multiple sclerosis (MS). Recent technical advances made progress in understanding the substrate
and mechanisms underlying the development and evolution of focal lesions and ‘diffuse’ damage
in MS as well as the functional consequences of such structural abnormalities. Higher-field MR
scanners and new positron emission tomography (PET) radio ligands has provided new insights into
cellular and pathophysiological abnormalities, and would be valuable in future therapeutic trials. This
review summarizes advanced MRI approaches for the investigation of lesion burden and understanding
of the pathophysiology of MS.
Journal of Multiple Sclerosis 4(2):36-43, 2013
keyword : Multiple sclerosis, Magnetic resonance imaging, Ultra-high field, Double inversion recovery, Iron
