Neuromyelitis Optica Spectrum Disorder without Anti-AQP4 Antibody after Treatment of Latent Syphilis
Ju Heon Lee, MD, Young Gi Lim, MD, Joo Yeon Ham, MD, Hee-Jung Song, MD, PhD, Ae Young Lee, MD, PhD, Eun Hee Sohn, MD, PhD
Department of Neurology, Chungnam National University, College of Medicine, Daejeon, Korea
Neuromyelitis optica spectrum disorder (NMOSD) is characterized by optic neuritis, longitudinally
extensive transverse myelitis (LETM), or area postrema syndrome. Chronic infection such as human
immunodeficiency virus or syphilis is one of the red flags of NMOSD. We report a case presenting
with LETM and area postrema lesion following treatment of latent syphilis. Syphilis might be one of
the causes of post-infectious NMOSD as well as one of causes of chronic CNS infection.
Journal of Multiple Sclerosis 7(2):59-62, 2016
